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The Francis Crick Institute
Senior Laboratory Research Scientist – Advanced Sequencing Facility
The Francis Crick Institute
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease.
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JOB DETAILS
Published: 28 days ago
Application deadline: Dec 08
Location: London, United Kingdom
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Senior Laboratory Research Scientist – Advanced Sequencing Facility

 Location:         The Francis Crick Institute, Midland road, London          
Contract:         Fixed-term (12 months), Full time
Salary:             Competitive with benefits, subject to skills and experience
Vacancy ID:     6264

SHORT INTRODUCTION/SUMMARY

This is a post within the Advanced Sequencing Facility (ASF), based at the Francis Crick Institute (FCI) and is linked to the Translational Cancer Therapeutics Laboratory, also at the FCI. The post holder will work as part of a team to provide specific sequencing support for the renal and melanoma TRACERx (TRAcking Cancer Evolution through therapy (Rx)) studies, led by Dr Samra Turajlic. The position will involve sample processing, quality control, library preparation, and targeted next-generation sequencing using Illumina NextSeq and HiSeq instruments in the ASF laboratory. The post holder will also be expected to troubleshoot and use their own initiative to overcome problems that may occur.

The post holder will have an excellent understanding of DNA and RNA sequencing techniques and a broad practical molecular biology skill set to allow them to develop and optimise experiments for large-scale genome analysis. This post will require cross training with other members of the ASF to allow cover of the facility as required. The post also dictates that the individual keep detailed records to aid in the laboratory quality check procedures and work closely with the TRACERx Laboratory Manager.

PROJECT SCOPE/ DESCRIPTION

The principal objectives of TRACERx Renal are to use Next Generation Sequencing methodologies to define drivers and intratumour heterogeneity in RCC and determine the relationship between heterogeneity and disease stage, clinical outcome and treatment response. Additional objectives include the identification of drivers of metastatic progression and drug response, or resistance and establishing the utility of cell-free tumour DNA in patients’ blood and urine as a predictive biomarker in RCC. Experience and methods gained from this sequencing work will also be used develop experimental approaches for the Melanoma TRACERx project.

The successful candidate will join the divese TRACERx team of surgeons, clinicians, pathologists, scientistis and bioinformaticians working together to address these challenges.

(for further information see www.tracerx.co.uk).

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

For further information contact samra.turajlic@crick.ac.uk

If you are interested in applying for this role, please apply via our website https://goo.gl/QxGy2w

The closing date for applications is 08 December 2017 at 23:30.
Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom. 

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