PhD: studying neurodegeneration using iPSC and xenotransplantation models

The research groups within the Center for Molecular Medicine are at the forefront of investigating neurodegenerative disorders, with a focus on Parkinson's disease and multiple system atrophy. Our mission is to gain deeper insights into the underlying mechanisms of neurodegenerative disorders and to develop new therapeutic interventions.

As part of these multidisciplinary research groups, we operate in a dynamic and challenging environment where fundamental research seamlessly transitions into drug discovery. Utilizing innovative technologies and advanced cell, organoid, and animal models, our aim is to develop novel humanized models for preclinical research. We are seeking a passionate PhD researcher to join our research team and contribute to the next steps of this investigation

Project

Parkinson's disease and multiple system atrophy belong to a broader family of brain disorders characterized by glial and neurodegenerative pathologies. The exact etiology of these diseases remains unclear, but recent studies suggest that oligodendroglial cells may be early contributors to the disease process of these brain disorders.

As a PhD student, you will be responsible for developing innovative oligodendroglial humanized cell and animal models. You will work with human induced pluripotent stem cells, which will be further transplanted into mouse models via xenotransplantation. This approach will enable the study of the role of human cells in Parkinson's disease and multiple system atrophy.

This project offers a unique opportunity to contribute to cutting-edge research on the causes and treatments of neurodegenerative disorders, while developing your own skills and expertise in a stimulating research environment.

Keywords: Neurodegeneration, human pluripotent stem cells, xenotransplantation, alpha-synuclein, animal models, multiple system atrophy, Parkinson's disease

Profile

• The candidate has a master's degree in medicine, biomedical sciences, pharmaceutical sciences, biology, bioscience engineering, biochemical sciences or a related discipline.
• Experience with human induced pluripotent stem cells (iPSCs) is a plus
• Experience with animals is a plus
• Top 25 for grades obtained during Bachelor/Master
• The candidate is motivated to work with complex cell cultures and laboratory animal
• Excellent oral English communication and presentation skills are required
• Passion for research and sense of perseverance
• Critical mind with a great sense of initiative
• Good interpersonal skills
• Since the candidate must apply for a PhD scholarship, a master's degree obtained in the European Union, the European Economic Area or Switzerland is a requirement.

Offer

• A full-time PhD position for 1 year, with the possibility of extension
• PhD training in the KUL doctoral school
• Work and collaborate with internationally leading multidisciplinary teams with relevant experience and expertise
• Support with the application for an FWO grant (applying for an FWO grant is a condition)
• If an FWO grant is not obtained, further funding will be considered 
• Competitive salary

Interested?

For more information please contact Prof. dr. Wouter Peelaerts, tel.: +32 16 37 40 59, mail: wouter.peelaerts@kuleuven.be.

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