Research assistent: Exploring the role of cell size on aging of human hematopoietic stem cells

Do you want to contribute to top quality medical research?

The failure to regenerate tissue with age is a major health issue. A contributor to this decline is the loss of stem cell function. Despite the essential role of stem cells, it is still unclear how they fail to maintain their functions during aging and disease. We discovered a new aspect of stem cell aging in vivo: cellular enlargement. With age and damage, stem cells increase in size causing their functional decline. However, we are only beginning to understand how size impacts stem cell fitness and the physiological importance of this process remains unsolved.

Your mission

Your project will utilize human hematopoietic stem cells to identify factors that facilitate stem cell aging and leukemia by single sequencing, creating xenotransplants using “humanized” mice and in vitro systems to investigate the underlying mechanisms.

Your profile

We are seeking a highly motivated and ambitious individual from universities around the world to join the research team of Assistant Professor Dr. Jette Lengefeld to mechanistically understand novel mechanisms of human stem cells that drive aging and disease. The Lengefeld research group uses hematopoietic stem cells from mice and human bone marrow donations to discover how deregulation of cellular size is connected to aging and cancer.

Special skills and attributes of the applicant:

Mandatory requirements

• Experience working in the hematology field
• At least 1 year of experience with hematopoietic stem and progenitor cells
• Cell culture experience: Cultivation of human and mouse cell lines and primary cells

Meritorious qualities 

• Experience in isolation of cells from human umbilical cord
• At least 6 months of research experience abroad
• Expertise in the field of viral transduction
• Knowledge in the field of molecular biology, especially cloning

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Flemingsberg

Department of Medicine, Huddinge (MedH) 

Lengefeld research group

 Choose to work at KI – Ten reasons why

Application

Welcome to apply at the latest 30th april, 2024.

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all

1. Jette Lengefeld, jette.lengefeld@ki.se

1. Sidinh Luc, SACO, sidinh.luc@ki.se
2. Belinda Pannagel, SACO, belinda.pannagel@ki.se
3. Mari Gilljam, OFR, mari.gilljam@ki.se