AIT Austrian Institute of Technology
PhD Thesis “Establishment and validation of in-vito models of the blood-saliva barrier
AIT Austrian Institute of Technology
The AIT Austrian Institute of Technology, Austria's largest non-university research institute, is among the European research institutes a specialist in the key infrastructure issues of the future.
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JOB DETAILS
Published: 2 months ago
Application deadline: Unspecified
Location: Vienna, Austria
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PhD Thesis “Establishment and validation of in-vito models of the blood-saliva barrier

We are Austria’s largest Research and Technology Organisation and an international player in the research areas that we cover. This makes us a leading development partner for industry and a top employer in the scientific community. Applications are invited for a:

PhD Thesis “Establishment and validation of in-vito models of the blood-saliva barrier

Saliva is a very attractive source for biomarker analysis, it is easily, non-invasively accessible and contains multiple types of molecules suitable for biomarker research (proteins, bacterial components, ncRNAs (miRNA, piwiRNA, IncRWA, circRNA), exosome content, …).Comparison to biomarkers obtained from blood revealed similarities, but also significant differences in the presence and regulation of biomarkers found in saliva in relation to the corresponding disease progression. Currently, although strong correlations between biomarkers and their indicated disease states exist, one important issue is the profound knowledge about how and why one biomarker appears in saliva is lacking. Therefore, the aim of this thesis is to develop primary cell based in-vito models of the blood-saliva barrier in order to study the relationship and interactions between the blood and the saliva compartment in health and disease. The first focus will be set on the establishment and characterization of models of salivary glands (e.g. epithelium of the glandula submandibularis) and the oral mucosa followed by using the developed models for drug and biomarker studies.

Description

  • Establishment of in-vitro models of the blood-saliva barrier based on primary cells
  • Validation of the models with regard to their barrier properties (paracellular barrier, transcellular transport barrier)
  • Influence of the microenvironment (e.g. endothelial cells, basal lamina, …) on barrier functionality
  • Application on the developed models for disease modelling (e.g. inflammation, infection)

Candidate profile

  • Master degree in molecular biology, biotechnology, pharmaceutical sciences or related field
  • Experimental skills in cell culture, protein analysis and molecular biology techniques
  • Ability to work in a team of researchers with a complementary expertise, guiding Master students at the beginning of their scientific carrier and publishing the results in leading scientific journals

Your compensation:

AT least € 2.045,10 gross for 30 hours per month standard personnel salaries for FWF project proposals

Please submit your application documents, including certificates, to

Maria Leonhard-Maurer, MSc, Head of Human Resources
maria.leonhard-maurer@ait.ac.at, +43 (0) 50550-2032
www.ait.ac.at

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