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Saliva is a very attractive source for biomarker analysis, it is easily, non-invasively accessible and contains multiple types of molecules suitable for biomarker research (proteins, bacterial components, ncRNAs (miRNA, piwiRNA, IncRWA, circRNA), exosome content, …).Comparison to biomarkers obtained from blood revealed similarities, but also significant differences in the presence and regulation of biomarkers found in saliva in relation to the corresponding disease progression. Currently, although strong correlations between biomarkers and their indicated disease states exist, one important issue is the profound knowledge about how and why one biomarker appears in saliva is lacking. Therefore, the aim of this thesis is to develop primary cell based in-vito models of the blood-saliva barrier in order to study the relationship and interactions between the blood and the saliva compartment in health and disease. The first focus will be set on the establishment and characterization of models of salivary glands (e.g. epithelium of the glandula submandibularis) and the oral mucosa followed by using the developed models for drug and biomarker studies.
AT least € 2.045,10 gross for 30 hours per month standard personnel salaries for FWF project proposals