The Developmental Neurobiology lab located in Brussels, Belgium is seeking junior postdocs with “international mobility” status (i.e. who did not reside or work in Belgium for more than 24 months in the last three years).
The main purpose of research in our laboratory is to understand the mechanisms underlying the development of the nervous system, with a particular emphasis on the role of cell polarity in neural development. We use several molecular and cellular methodologies, including embryonic stem cells, transgenic mice design & production, neuroanatomy, live imaging, slice culture, as well as other in vitro assays (See selected publications below).
The positions are funded on a yearly basis for up to 3-4 years. Selected candidates will analyze the neural phenotype of mouse models bearing gain and/or loss of function mutations. These models are homemade and already available in the lab. In utero electroporation will be used in some cases to overexpress specific genes.
Expertise in cell biology and live imaging is required. Candidates with developmental neurobiology background will be preferred.
For applications, please email email@example.com
Tissir F, Bar I, Jossin Y, De Backer O, Goffinet AM (2005). Protocadherin Celsr3 is crucial in axonal tract development. Nature Neuroscience 8(4): 451-7.
Zhou L, Bar I, Achouri Y, Campbell K, De Backer O, Hebert JM, Jones K, Kessaris N, de Rouvroit CL, O'Leary D, Richardson WD, Goffinet AM, Tissir F (2008). Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice. Science 320(5878): 946-9.
Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy P, Poumay Y, Uemura T, Goffinet AM (2010). Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis leading to fatal hydrocephalus. Nature Neuroscience 13(6): 700-707
Tissir F & Goffinet AM (2013). Shaping the nervous system: Role of the planar cell polarity genes. Nature Reviews Neuroscience 14: 525-535
Chai G, Zhou L, Manto M, Helmbacher F, Clotman F, Goffinet AM, Tissir F (2014). Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nature Neuroscience 17: 1171-1179.