KU Leuven
POSTDOC POSITION IN LEUKEMIA RESEARCH
KU Leuven
KU Leuven is an autonomous university. It was founded in 1425. It was born of and has grown within the Catholic tradition.
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JOB DETAILS
Published: 4 days ago
Application deadline: May 31
Location: Leuven, Belgium
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POSTDOC POSITION IN LEUKEMIA RESEARCH

(Ref. BAP-2017-200)

Occupation : Full-time
Period : Fixed-term contract
Place : Leuven
Apply no later than : May 31, 2017

For the Laboratory of Molecular Biology of Leukemia we are looking for a highly motivated postdoctoral researcher for studies of oncogenic pathways in leukemia mouse models.

POSTDOC POSITION IN LEUKEMIA RESEARCH

The Laboratory of Molecular Biology of Leukemia of Professor Jan Cools is located on the Gasthuisberg Campus of KU Leuven, Faculty of Medicine, Center for Human Genetics and has on-site mouse facilities, sequence facilities and access to leukemia samples. 
The Laboratory is also part of one of the research Centers of VIB: the Center for Cancer Biology (CCB). The VIB is an exciting, interdisciplinary research institute with excellent facilities and strong research groups in genetics, oncology, neurobiology, immunology, virology, molecular biology and translational research.

Recent publications

De Keersmaecker K, et al. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nature Genetics. 2013; 45(2):186-90.
Dagklis A, et al. Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors. Blood. 2016; 128(23):2642-2654.
Vicente C, et al. Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia. Haematologica. 2015; 100(10):1301-10.

Website unit

Responsibilities

The project will focus on (i) leukemia mouse models by use of transgenic animals as well as bone marrow transplant assays; (ii) the study of transcription factor binding to DNA by ChIP-seq; (iii) the effect on transcription by other mutations.

Profile

  • PhD in biology, biochemistry, biotechnology or equivalent
  • Broad expertise in basic research technology (Western blotting, gene expression, cell culture, flow cytometry, etc.)
  • Good publication record and strong communication skills
  • Experience with transcription factors, ChIP-seq, RNA-seq, etc. is a plus
  • Experience with xenograft mouse models is a plus

This position is open to both junior and experienced scientists. We look for highly motivated candidates with an interest in leukemia research and with a track record in cell biology, mouse models and/or transcription factor function. We provide a stimulating and strong scientific environment.

Offer

The Center for Human Genetics (KU Leuven) and the Center for Cancer Biology (VIB) entail an interactive and stimulating work and training environment with a dynamic and diverse scientific community and access to state-of-the-art core facilities to successfully perform multidisciplinary research.

Interested?

For more information please contact Prof. dr. Jan Cools, tel.: +32 16 33 00 82, mail: jan.cools@kuleuven.vib.be.

You can apply for this job no later than May 31, 2017 via the online application tool

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